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During prophylactic administration of mefloquine to indigenous populations in malaria-endemic areasthe following occasional alterations in laboratory values were observedtransient elevation of transaminasesleukocytosis or thrombocytopenia.

Patients should be managed by symptomatic and supportive care following LariammefloquineoverdoseThere are no specific antidotesMonitor cardiac functionif possible by ECGand neuropsychiatric status for at least 24 hoursProvide symptomatic and intensive supportive treatment as requiredparticularly for cardiovascular disturbances.

Halofantrinemarketed under various brand namesa medicine used to treat malariaTaking both of these medicines together can cause serious heart problems that can cause deathDo not become pregnantWomen should use effective birth control while taking LariammefloquineQuininequinidineor chloroquineother medicines used to treat malariaTaking these medicines with Lariammefloquinecould cause changes in your heart rate or increase the risk of seizures.

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it is documented that lariam can cause hallucinations, paranoid or aggressive behavior, and personality changes.