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Many drugs can interact with metforminmaking it less effective or increasing your risk of lactic acidosisThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed hereTell your doctor about all your current medicines and any medicine you start or stop using.

Kidney diseaseyour kidney function may need to be checked before you take this medicine

Increased risk of lactic acidosis with topiramateother carbonic anhydrase inhibitorsegzonisamideacetazolamidedichlorphenamidemonitorConcomitant cationic drugs that interfere with renal tubular transport systemsegranolazinevandetanibdolutegravircimetidinemay increase metformin levelsmonitorAvoid excessive alcohol intakepotentiates effects of metformin on lactateDiureticssteroidsphenothiazinesthyroid productsestrogensoral contraceptivesphenytoinsympathomimeticscalcium channel blockersisoniazidnicotinic acidothers may cause hyperglycemiaMay need lower dose of concomitant insulin and/or insulin secretagogueegsulfonylureato reduce risk of hypoglycemia.

Should generally be avoided in patients with clinical or laboratory evidence of hepatic diseasepatients should be cautioned against excessive alcohol intakeeither acute or chronicduring metformin therapy because alcohol potentiates the effects of metformin on lactate metabolism.

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