Coffee can reduce pain sensitivity when deprived of sleep (Image: Getty Images)Get daily news updates directly to your inboxSubscribeSee our privacy noticeThank you for subscribing!In experiments groups of six to 12 lab rodents were kept awake for as long as 12 hours for one group and six hours for five consecutive days for another.Then they were exposed to extreme heat, cold, pressure or capsaicin, the chemical in hot chilli peppers.By measuring how long it took the animal to move away or lick away the discomfort caused by capsaicin, the researchers showed caffeine blocked sensitivity to the pain.As teenage boy ‘beats’ cancer with cannabis oil here are nine illnesses the drug could ‘cure'(Image: Getty Images)Dopamine boosting drug modafinil also had the same effect. But in mice not deprived of sleep the compounds had no pain relieving properties.Sleep physiologist Dr Chloe Alexandre, of Beth Israel Deaconess Medical Centre in Boston, said: “We found that five consecutive days of moderate sleep deprivation can significantly exacerbate pain how much does prazosin lower blood pressure sensitivity over time in otherwise healthy mice.”The response was specific to pain, and was not due to a state of general hyper excitability to any stimuli.”Surprisingly, common analgesics like ibuprofen did not block increased pain sensitivity caused by sleep loss. Even morphine lost most of its effect.Dr Alexandre said this suggests patients using these drugs for pain relief might have to increase their dose, increasing their risk for side effects.Caffeine and modafinil are both drugs used to promote wakefulness, she said.Rather than just taking painkillers, patients with chronic pain might benefit from sleeping pills coupled with regular daytime doses of caffeine.Drug that reverses ageing could be available to buy in just three years timeSome painkillers already include caffeine as an ingredient although its mechanism of action isn’t yet known.Both caffeine and modafinil boost dopamine circuits in the brain, so that may provide a clue.Dr Kiran Maski, a specialist in sleep disorders at Boston Children’s Hospital, said: “Many patients with chronic pain suffer from poor sleep and daytime fatigue, and some pain medications themselves can contribute to these co morbidities,””This study suggests a novel approach to pain management that would be relatively easy to implement in clinical care.”Clinical research is needed to understand what sleep duration is required and to test the efficacy of wake promoting medications in chronic pain patients.”The study published in Nature Medicine used tiny headsets that took ERG (electroencephalography) and EMG (electromyography) readings for each mouse.Pain physiologist Dr Alban Latremoliere, of Boston Children’s Hospital, said: “For each mouse, we have exact baseline data on how much they sleep and what their sensory sensitivity is.”.

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