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Methotrexate must not be used during pregnancyIt may harm an unborn babyIt is important to prevent pregnancy during and after treatment with methotrexateThereforemales and females must use reliable forms of birth controlsuch as condomsbirth control pillsduring treatmentMales should continue to use birth control for at least 3 months after the end of treatmentFemales should continue to use birth control for at least 1 menstrual cycle after the end of treatmentIf you become pregnant or think you may be pregnanttell your doctor right away.

In rare instancesthis drug may also cause liver problems when it is used for long periods of timeIf you are using methotrexate long terma liver biopsy is usually recommended.

Methotrexate should NOT be taken if you are pregnant or planning to get pregnant or breast-feedingMethotrexate may be temporarily discontinued if you are having surgeryincluding dental surgeryInform your surgeon or dentist about the medication prior to the surgeryMethotrexate sensitises your skin to sunlightAvoid unnecessary or prolonged sun exposure and wear protective gearIf you have psoriasisyour sores may worsen if you expose your skin to sunlight while you are taking methotrexateVaccinationsespecially live onesare not to be given while you are taking methotrexateDiscuss this with your doctor for safer options.

When this medication is used with radiation treatmentit may rarely increase the risk of tissue and bone damageDiscuss the risks and benefits of your treatment with your doctor.

12 mg/m2 intrathecally every 2 to 5 days until the cell count of the CSF returns to normalAt this pointone additional dose is advisableAdministration at intervals of less than 1 week may result in increased subacute toxicity.

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