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As adjunctive therapy for short-term administrationto tide the patient over an acute episode or exacerbationin acute gouty arthritisacute rheumatic carditisankylosing spondylitispsoriatic arthritisrheumatoid arthritisincluding juvenile rheumatoid arthritisselected cases may require low-dose maintenance therapyFor the treatment of dermatomyositispolymyositisand systemic lupus erythematosus.

Latent disease may be activated or there may be an exacerbation of intercurrent infections due to pathogensincluding those caused by AmoebaCandidaCryptococcusMycobacteriumNocardiaPneumocystistoxoplasmarule out latent amebiasis or active amebiasis before initiating corticosteroid therapy in any patient who has spent time in the tropics or any patient with unexplained diarrhea.

Corticosteroids have been shown to be teratogenic in many species when given Yasmin birth control no prescription in doses equivalent to the human doseAnimal studies in which corticosteroids have been given to pregnant miceratsand rabbits have yielded an increased incidence of cleft palate in the offspringThere are no adequate and well-controlled studies in pregnant womenCorticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetusInfants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.

Primary or secondary adrenocortical insufficiencyhydrocortisone or cortisone is the first choicemay be used in conjunction with synthetic mineralocorticoid analogs where applicablein infancy mineralocorticoid supplementation is of particular importancecongenital adrenal hyperplasiahypercalcemia associated with cancerand nonsuppurative thyroiditis.

Average and large doses of corticosteroids can cause elevation of blood pressuresodium and water retentionand increased excretion of potassiumThese effects are less likely to occur with the synthetic derivatives except when used in large dosesDietary salt restriction and potassium supplementation may be necessaryAll corticosteroids increase calcium excretion.

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