The strongest evidence for the use of dapoxetine in adult males with premature ejaculation is for the main disease-oriented outcome of ielt, reported in seven of the nine publications identified in our literature search see table 4 .

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Dapoxetine is a safe and effective treatment for premature ejaculationPEbut it has a high discontinuation rateaccording to new research.

Dapoxetinea novel selective serotonin transport inhibitor for the treatment of premature ejaculation.

A quarter of the men stopped taking dapoxetine because they were disappointed that PE was incurable and that dapoxetine had to be taken before sex.

A quarter of the men stopped taking dapoxetine because they were trileptal mood disorder disappointed that PE was incurable and that dapoxetine had to be taken before sex.

1 Department of UrologySisli Etfal Training and Research HospitalIstanbulTurkey.

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dapoxetine is contraindicated in men with moderate to severe hepatic impairment and in those receiving concomitant therapy with potent cytochrome p450 3a4 inhibitors eg, ketoconazole, ritonavir, telithromycin , thioridazine, monoamine oxidase inhibitors, serotonin reuptake inhibitors eg, ssris, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants or other medicinal herbal products with serotonergic effects eg, hypericum st john s wort .