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Keppra must not be used in people who are hypersensitiveallergicto levetiracetamto other pyrrolidone derivativesmedicines with a similar structure to levetiracetamor to any of the other ingredients.

A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetamExperimental data indicate that this binding site is the synaptic vesicle protein SV2Athought to be involved in the regulation of vesicle exocytosisAlthough the molecular significance of levetiracetam binding to SV2A is not understoodlevetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity retin-a micro delivery system in audiogenic seizure-prone miceThese findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.

Levetiracetam induces seizure protection in a broad range of animal models of partial and primary generalised seizures without having a pro-convulsant effectThe primary metabolite is inactive.

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the abuse and dependence potential of keppra has not been evaluated in human studies.