Darunavir and viramune can be co-administered without dose adjustments.

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Clarithromycin exposure was significantly decreased14-OH metabolite exposure increasedBecause the clarithromycin active metabolite has reduced activity against Mycobacterium avium-intracellulare complex overall activity against the pathogen may be alteredAlternatives to clarithromycinsuch as azithromycin should be consideredClose monitoring for hepatic abnormalities is recommended.

While effective viral suppression with antiretroviral therapy has been proven to substantially reduce the risk of sexual transmissiona residual risk cannot be excludedPrecautions to prevent transmission should be taken in accordance with national guidelines.

Discontinue immediately if severe skin or hypersensitivity reactions occur or if any rash with systemic symptoms occurs.

The Committee noted that most of the experience with Viramune was in combination with nucleoside reverse-transcriptase inhibitorsNRTIsa type of antiviral medicineand that there was insufficient evidence on the use of combination treatment including a protease inhibitoranother type of antiviral medicineafter Viramune treatmentThe Committee recommended that Viramune be given marketing authorisation.

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this is a retrospective multicentre study comparing the 3-year antiviral efficacy of viramune and efavirenz in combination with stavudine and lamivudine in 2nn patients from week 49 to week 144.