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Clopidogrel is used to prevent heart attacks and strokes in persons with heart diseaserecent heart attackrecent strokeor blood circulation diseaseperipheral vascular disease

DUse in LIFE-THREATENING emergencies when no safer drug availablePositive evidence of human fetal risk.

A randomizedplacebo-controlled trialCLARINETdid not demonstrate a clinical benefit of clopidogrel in neonates and infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary arterial shuntPossible factors contributing to this outcome were the dose of clopidogrelthe bladder infection treatment pyridium concomitant administration of aspirin and the late initiation of therapy following shunt palliationIt cannot be ruled out that a trial with a different design would demonstrate a clinical benefit in this patient population.

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the hypothetical comparison with generic clopidogrel is important because the patent exclusivity for plavix will expire in 2011 or 2012.